Lubric Advanced™ Angiographic Guidewires

The Lubric Advanced™ hydrophilic angiographic guidewire is a single-use, sterile peripheral vascular guidewire designed for interventional radiologists and vascular surgeons who need reliable, low-friction vascular access across the full range of diagnostic and interventional peripheral procedures. Combining a high-tensile stainless steel core, a tungsten-loaded polyurethane outer jacket, and a long-lasting hydrophilic surface coating, the Lubric Advanced™ delivers the three properties that define a clinically dependable peripheral vascular guidewire: fluoroscopic visibility, precise torque transmission, and ultra-low friction navigation through tortuous vascular anatomy.

Designed and manufactured in-house by Hainwise Medical Technology Co., Ltd. under an ISO 13485-certified quality management system, the Lubric Advanced™ is available in Standard and Stiff core configurations, multiple tip shapes, and a comprehensive range of diameters and working lengths—with full OEM customization and private label support for global distribution partners.

HW™ Angiographic Guidewire is composed of a stainless steel core wire, tungsten-loaded polyurethane cladding, and a hydrophilic coating.

Layer 1 — High-Tensile Stainless Steel Core

The structural foundation of the hydrophilic angiographic guidewire is a precision-ground stainless steel core wire. Stainless steel was chosen over nitinol for this design because the Lubric Advanced™ is optimized for torque-demanding diagnostic procedures where the operator needs predictable, one-to-one torque transmission from the proximal handle to the distal tip—particularly during selective catheter placement in branching vascular anatomy (mesenteric, renal, iliac, and hepatic artery branches).

Stainless steel delivers:

• High column strength — consistent pushability without wire prolapse in large-lumen vessels (aorta, iliac system, subclavian)

• Reliable 1:1 torque response — precise tip control during selective angiography, where the catheter must be steered into specific vessel orifices

• Kink resistance across working lengths — the wire maintains structural integrity from access site to distal tip, even when multiple bends are traversed simultaneously

Layer 2 — Tungsten-Loaded Polyurethane Outer Jacket

Overlying the stainless steel core is a tungsten-filled polyurethane cladding layer—the element that makes the Lubric Advanced™ angiographic guidewire visible under fluoroscopy throughout its entire working length.

Tungsten is significantly denser than conventional radiopaque marker materials, giving the polyurethane jacket exceptional X-ray attenuation. The clinical consequence is a guidewire that is continuously visible under fluoroscopy from the access point to the distal tip—not just at discrete marker bands. This full-length fluoroscopic visibility enables the interventionalist to:

• Confirm wire trajectory through vessel bifurcations before advancing the catheter

• Monitor wire position during catheter exchange without losing spatial orientation

• Immediately detect any unintended wire migration during multi-step procedures

• Reduce total fluoroscopy time by providing continuous positional reference without repositioning the X-ray field

The polyurethane jacket also provides a smooth mechanical transition layer between the rigid stainless steel core and the hydrophilic surface coating, preventing coating delamination under repeated bending stress.

Layer 3 — Persistent Hydrophilic Surface Coating

The outermost layer of the Lubric Advanced™ is a hydrophilic polymer coating that activates on contact with blood or saline, forming a sustained fluid lubricating layer across the wire's surface. The clinical consequence is dramatically reduced frictional resistance during:

• Wire advancement through long vessel segments (iliac-to-renal artery access, subclavian-to-axillary approaches)

• Navigation through tight atherosclerotic stenoses where a PTFE-coated wire would generate resistance spikes

• Rapid catheter exchanges, where repeated catheter movement over the wire must not disturb wire position

The coating is engineered for durability under repetitive motion—validated to maintain lubricity across a defined number of catheter exchange cycles, ensuring consistent friction reduction throughout extended interventional procedures rather than degrading after initial wetting.

① Ultra-Low Friction Catheter Delivery in Tortuous Anatomy

The defining clinical advantage of a hydrophilic angiographic guidewire over a PTFE-coated wire is friction reduction in difficult vascular anatomy. In patients with atheromatous iliac disease, tortuous abdominal aortas, or hostile access anatomy following prior surgery, the Lubric Advanced™'s hydrophilic surface allows the catheter to track smoothly over the wire without the resistance spikes that can cause abrupt catheter advancement or inadvertent wire displacement.

This is particularly valuable in:

• Transradial approaches where the long wire path through subclavian and brachiocephalic vessels amplifies friction effects

• Obese patients where the longer working distance increases cumulative friction

• Repeat-access cases where vessel trauma from prior procedures has increased resistance

② Full-Length Fluoroscopic Visualization via Tungsten Jacket

Unlike radiopaque tip-only wires that require the operator to estimate wire body position from the tip location alone, the tungsten-loaded jacket of the peripheral vascular guidewire makes the complete wire shaft visible throughout the procedure. This reduces both cognitive load and radiation exposure—operators can confirm wire anatomy with a brief fluoroscopic check rather than extended cine runs.

③ Precise Torque Transmission for Selective Catheterization

During selective angiography, the catheter tip must be positioned precisely within target vessel orifices (celiac axis, superior mesenteric artery, renal arteries, bronchial arteries). This requires reliable torque transmission from the operator's hand through the full wire length to produce predictable tip rotation. The stainless steel core of the Lubric Advanced™ provides this predictability—ensuring that a 90-degree handle rotation translates to a predictable arc at the distal tip, enabling efficient selective catheterization with fewer rotational maneuvers.

④ Atraumatic Tip Design Across All Configurations

Whether configured with a standard flexible tip or a stiff reinforced tip, the Lubric Advanced™ distal tip geometry is specifically designed to be atraumatic—deflecting at vessel walls and bifurcations rather than puncturing or dissecting intima. The floppy distal segment absorbs contact force before the stiffer proximal shaft can transmit it to the vessel wall.

Configuration Options — Standard vs. Stiff vs. Reinforced

The Lubric Advanced™ hydrophilic angiographic guidewire is available in three core stiffness configurations to match different procedural demands:

Hainwise supports customized configurations including:

● Diameter and length adjustments

● Core stiffness modification

● Coating variations

● Tip shaping options

● Packaging and labeling customization

OEM and private label solutions available for global partners.

● Manufactured under EN ISO 13485 certified quality management system

● Full batch traceability

● Validated manufacturing processes

● Compliance documentation available upon request

Frequently Asked Questions

Q: What makes a hydrophilic angiographic guidewire preferable to a PTFE-coated wire for peripheral procedures?

A:A PTFE-coated wire provides consistent, moderate friction reduction but does not become lubricious on contact with fluid—it performs similarly whether dry or wet. A hydrophilic coating activates on wetting, producing significantly lower friction—often measured at substantially less surface resistance than PTFE. This difference matters most in tortuous anatomy, resistant stenoses, and long-reach access scenarios where cumulative friction along the wire path can impede smooth catheter delivery or cause abrupt catheter advancement.

Q: Why does the Lubric Advanced™ use a stainless steel core rather than nitinol?

A:The Lubric Advanced™ is optimized for diagnostic angiographic and interventional radiology procedures where torque transmission and column strength are primary requirements. Stainless steel provides superior 1:1 torque response and consistent pushability for selective catheterization in large peripheral vessels. Nitinol, with its superior kink resistance and flexibility, is preferred for applications requiring navigation in smaller, more tortuous vessels where shape retention after extreme deflection is more critical than torque accuracy—such as the Hainwise Medusa™ controllable guidewire range.

Q: What is the significance of the tungsten-loaded polyurethane jacket versus conventional spring coil tip fluoroscopic markers?

A:Conventional angiographic guidewires provide fluoroscopic visibility only at the distal tip (via a short radiopaque coil or marker). The tungsten-infused jacket of the Lubric Advanced™ angiographic guidewire provides continuous X-ray visibility across the full wire length—enabling real-time tracking of the entire wire path, not just the tip position. This is clinically significant during selective catheterization, catheter exchanges, and complex multi-vessel procedures where body position tracking prevents positional errors.

Q: How long does the hydrophilic coating maintain its lubricity during an extended procedure?

A:The Lubric Advanced™ hydrophilic coating is validated to maintain consistent lubricity throughout a defined number of catheter exchange cycles representative of complex peripheral interventions. Unlike some hydrophilic coatings that degrade rapidly on repeated mechanical contact, the Lubric Advanced™ coating is formulated for durability under procedural conditions. Contact our technical team for specific lubricity validation data.

Q: Can the Lubric Advanced™ be used for transradial peripheral access procedures?

A:Yes. The Lubric Advanced™ hydrophilic coating is particularly beneficial in transradial approaches to peripheral vessels, where the long wire path from the radial access site to distal peripheral targets substantially amplifies friction effects. The hydrophilic surface reduces frictional resistance along the full radial-subclavian-aortic-peripheral course, facilitating catheter delivery that would be significantly more challenging with a PTFE-coated wire over the same distance.

Q: What is the compatible catheter for the Lubric Advanced™?

A:The Lubric Advanced™ is compatible with standard diagnostic and interventional catheters designed for 0.035" or 0.038" guidewires (depending on selected wire diameter). For a matched catheter from the same manufacturer, the Mercury™ Angiographic Catheter from Hainwise's peripheral vascular portfolio is engineered for compatibility with the Lubric Advanced™ guidewire system.

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